{"id":35078,"date":"2025-07-09T14:08:34","date_gmt":"2025-07-09T07:08:34","guid":{"rendered":"https:\/\/www.asianbioplex.com\/shop\/uncategorized\/bicowhite-complex"},"modified":"2025-12-08T15:52:34","modified_gmt":"2025-12-08T08:52:34","slug":"bicowhite-complex","status":"publish","type":"product","link":"https:\/\/www.asianbioplex.com\/en\/shop\/extracts-for-cosmetics\/bicowhite-complex","title":{"rendered":"Bicowhite\u00ae Complex"},"content":{"rendered":"<h3><strong data-start=\"188\" data-end=\"210\">Bicowhite\u00ae Complex\u00a0<\/strong><\/h3>\n<article class=\"text-token-text-primary w-full focus:outline-none [--shadow-height:45px] has-data-writing-block:pointer-events-none has-data-writing-block:-mt-(--shadow-height) has-data-writing-block:pt-(--shadow-height) [&amp;:has([data-writing-block])&gt;*]:pointer-events-auto [content-visibility:auto] supports-[content-visibility:auto]:[contain-intrinsic-size:auto_100lvh] scroll-mt-[calc(var(--header-height)+min(200px,max(70px,20svh)))]\" dir=\"auto\" data-turn-id=\"75f1bb52-8b40-4899-bc55-96020756615e\" data-testid=\"conversation-turn-486\" data-scroll-anchor=\"true\" data-turn=\"assistant\">\n<div class=\"text-base my-auto mx-auto pb-10 [--thread-content-margin:--spacing(4)] thread-sm:[--thread-content-margin:--spacing(6)] thread-lg:[--thread-content-margin:--spacing(16)] px-(--thread-content-margin)\">\n<div class=\"[--thread-content-max-width:40rem] thread-lg:[--thread-content-max-width:48rem] mx-auto max-w-(--thread-content-max-width) flex-1 group\/turn-messages focus-visible:outline-hidden relative flex w-full min-w-0 flex-col agent-turn\">\n<div class=\"flex max-w-full flex-col grow\">\n<div class=\"min-h-8 text-message relative flex w-full flex-col items-end gap-2 text-start break-words whitespace-normal [.text-message+&amp;]:mt-1\" dir=\"auto\" data-message-author-role=\"assistant\" data-message-id=\"9edab18e-fac6-44f7-9559-cf97ac9ab9bc\" data-message-model-slug=\"gpt-5\">\n<div class=\"flex w-full flex-col gap-1 empty:hidden first:pt-[1px]\">\n<div class=\"markdown prose dark:prose-invert w-full break-words light markdown-new-styling\">\n<p data-start=\"0\" data-end=\"505\">Bicowhite\u00ae Complex is a multi-target delivery system for brightening and evening the skin tone, developed using Bicosome\u00ae Technology by BICOSOME, S.L., Spain. It is made from 95.3% natural ingredients and contains five key actives encapsulated within Smart Disk structures: Niacinamide, 3-O-Ethyl Ascorbic Acid, Potassium Azeloyl Diglycinate, Bisabolol, and Phytic Acid. These actives work synergistically to inhibit the formation of dark spots from the very beginning of the pigmentation process.<\/p>\n<p data-start=\"507\" data-end=\"800\">The product is designed to address the main challenges of typical brightening formulations by offering both high efficacy and excellent skin tolerance. It targets only areas with hyperpigmentation without damaging skin structure, and it can be used year-round without causing photosensitivity.<\/p>\n<p data-start=\"802\" data-end=\"952\" data-is-last-node=\"\" data-is-only-node=\"\">It is ideal for individuals seeking to reduce dark spots, melasma, and freckles while achieving brighter, more even-toned, and healthier-looking skin.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"z-0 flex min-h-[46px] justify-start\"><\/div>\n<\/div>\n<\/div>\n<\/article>\n<table dir=\"ltr\" border=\"1\" cellspacing=\"0\" cellpadding=\"0\">\n<colgroup>\n<col width=\"219\" \/>\n<col width=\"492\" \/> <\/colgroup>\n<tbody>\n<tr>\n<th>Subject<\/th>\n<th>Description<\/th>\n<\/tr>\n<tr>\n<td>Appearance<\/td>\n<td>Liquid<\/td>\n<\/tr>\n<tr>\n<td>pH<\/td>\n<td>4.0 &#8211; 6.0<\/td>\n<\/tr>\n<tr>\n<td><span data-sheets-root=\"1\">Composition<\/span><\/td>\n<td>-AQUA Up to 100<br \/>\n-LECITHIN 5-25%<br \/>\n-LYSOLECITHIN 2-20%<br \/>\n-LACTOBACILLUS FERMENT 1-5%<br \/>\n-NIACINAMIDE 1-5%<br \/>\n-3-0-ETHYL ASCORBIC ACID 1-5%<br \/>\n-POTASSIUM AZELOYL DIGLYCINATE 1-5%<br \/>\n-BISABOLOL 0.1-1.0%<br \/>\n-PHYTIC ACID 0.1 \u2013 0.5%<\/td>\n<\/tr>\n<tr>\n<td>Applications<\/td>\n<td>Cosmetic products<\/td>\n<\/tr>\n<tr>\n<td>Suggested Concentration<\/td>\n<td>1 &#8211; 3%<\/td>\n<\/tr>\n<tr>\n<td><span data-sheets-root=\"1\">Function<\/span><\/td>\n<td>Whitening<\/td>\n<\/tr>\n<tr>\n<td>INCI Name<\/td>\n<td>Water, Lecithin, Lysolecithin, Lactobacillus<br \/>\nFerment, Niacinamide, 3-O-Ethyl Ascorbic Acid,<br \/>\nPotassium Azeloyl Diglycinate, Bisabolol,<br \/>\nPhytic Acid, Tocopherol, Beta-Sitosterol, Squalene<\/td>\n<\/tr>\n<tr>\n<td>Storage conditions<\/td>\n<td><span data-sheets-root=\"1\">Store the product tightly closed in a dry place at no more than 8\u00baC and protected from light. <\/span><span data-sheets-root=\"1\">It is recommended to stir the full content of the container before use or fractioning to assure adequate<br \/>\nhomogeneity.<br \/>\nUse soon after opening the package.<br \/>\nThe stability studies data indicate the product can be<br \/>\ntransported and manipulated at temperature of 25\u00baC without instability risks.<\/span><\/td>\n<\/tr>\n<tr>\n<td>Shelf-Life<\/td>\n<td>24 months from manufacturing date<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p data-start=\"0\" data-end=\"394\">Bicowhite\u00ae Complex stands out for its innovative delivery system that transports five active ingredients simultaneously to targeted skin layers using Bicosome\u00ae Technology. This system features a dual structure composed of an outer lipidic vesicle and internal Smart Disks that encapsulate all five key actives. Each ingredient targets a specific stage of the melanin-production process:<\/p>\n<ul data-start=\"396\" data-end=\"745\">\n<li data-start=\"396\" data-end=\"462\">\n<p data-start=\"398\" data-end=\"462\">Potassium Azeloyl Diglycinate \u2013 inhibits melanin synthesis<\/p>\n<\/li>\n<li data-start=\"463\" data-end=\"549\">\n<p data-start=\"465\" data-end=\"549\">3-O-Ethyl Ascorbic Acid \u2013 prevents oxidation and darkening of existing pigment<\/p>\n<\/li>\n<li data-start=\"550\" data-end=\"618\">\n<p data-start=\"552\" data-end=\"618\">Niacinamide \u2013 prevents the transfer of melanin to skin cells<\/p>\n<\/li>\n<li data-start=\"619\" data-end=\"696\">\n<p data-start=\"621\" data-end=\"696\">Bisabolol \u2013 reduces inflammation that can trigger excess pigmentation<\/p>\n<\/li>\n<li data-start=\"697\" data-end=\"745\">\n<p data-start=\"699\" data-end=\"745\">Phytic Acid \u2013 promotes skin cell renewal<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"747\" data-end=\"1079\">In vitro studies show that Bicowhite\u00ae Complex reduces pigmentation by up to 32% within 4 days, while maintaining better skin structure compared to Kojic Acid.<br data-start=\"909\" data-end=\"912\" \/>Ex vivo testing on UV-exposed skin demonstrated a 154% reduction in pigmentation after 10 days, confirming its effectiveness even under strong sunlight conditions.<\/p>\n<p data-start=\"1081\" data-end=\"1326\" data-is-last-node=\"\" data-is-only-node=\"\">The product has passed safety evaluations, including non-irritant and non-phototoxic tests, and is certified Vegan, Non-GMO, and China NMPA Compliant.<br data-start=\"1251\" data-end=\"1254\" \/>Recommended usage level: 1\u20133% in all types of skincare formulations.<\/p>\n<p>&nbsp;<\/p>\n<h3>Mechanism of action<\/h3>\n<h3 data-start=\"1444\" data-end=\"1642\"><img decoding=\"async\" class=\"size-medium wp-image-35075 aligncenter\" src=\"https:\/\/www.asianbioplex.com\/wp-content\/uploads\/2025\/07\/beautiful-asian-woman-posing-with-facial-cream-300x200.webp\" alt=\"beautiful-asian-woman-posing-with-facial-cream\" width=\"300\" height=\"200\" srcset=\"https:\/\/www.asianbioplex.com\/wp-content\/uploads\/2025\/07\/beautiful-asian-woman-posing-with-facial-cream-300x200.webp 300w, https:\/\/www.asianbioplex.com\/wp-content\/uploads\/2025\/07\/beautiful-asian-woman-posing-with-facial-cream-1024x683.webp 1024w, https:\/\/www.asianbioplex.com\/wp-content\/uploads\/2025\/07\/beautiful-asian-woman-posing-with-facial-cream-768x512.webp 768w, https:\/\/www.asianbioplex.com\/wp-content\/uploads\/2025\/07\/beautiful-asian-woman-posing-with-facial-cream-1536x1024.webp 1536w, https:\/\/www.asianbioplex.com\/wp-content\/uploads\/2025\/07\/beautiful-asian-woman-posing-with-facial-cream-2048x1365.webp 2048w, https:\/\/www.asianbioplex.com\/wp-content\/uploads\/2025\/07\/beautiful-asian-woman-posing-with-facial-cream-750x500.webp 750w, https:\/\/www.asianbioplex.com\/wp-content\/uploads\/2025\/07\/beautiful-asian-woman-posing-with-facial-cream-600x400.webp 600w, https:\/\/www.asianbioplex.com\/wp-content\/uploads\/2025\/07\/beautiful-asian-woman-posing-with-facial-cream-272x182.webp 272w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/h3>\n<article class=\"text-token-text-primary w-full focus:outline-none [--shadow-height:45px] has-data-writing-block:pointer-events-none has-data-writing-block:-mt-(--shadow-height) has-data-writing-block:pt-(--shadow-height) [&amp;:has([data-writing-block])&gt;*]:pointer-events-auto scroll-mt-[calc(var(--header-height)+min(200px,max(70px,20svh)))]\" dir=\"auto\" data-turn-id=\"request-692fea12-84e8-832a-a25d-d6b69cca41c9-8\" data-testid=\"conversation-turn-62\" data-scroll-anchor=\"true\" data-turn=\"assistant\">\n<div class=\"text-base my-auto mx-auto pb-10 [--thread-content-margin:--spacing(4)] @w-sm\/main:[--thread-content-margin:--spacing(6)] @w-lg\/main:[--thread-content-margin:--spacing(16)] px-(--thread-content-margin)\">\n<div class=\"[--thread-content-max-width:40rem] @w-lg\/main:[--thread-content-max-width:48rem] mx-auto max-w-(--thread-content-max-width) flex-1 group\/turn-messages focus-visible:outline-hidden relative flex w-full min-w-0 flex-col agent-turn\">\n<div class=\"flex max-w-full flex-col grow\">\n<div class=\"min-h-8 text-message relative flex w-full flex-col items-end gap-2 text-start break-words whitespace-normal [.text-message+&amp;]:mt-1\" dir=\"auto\" data-message-author-role=\"assistant\" data-message-id=\"db50a7e8-4816-46c1-8922-a69dbdf01d4b\" data-message-model-slug=\"gpt-5-1\">\n<div class=\"flex w-full flex-col gap-1 empty:hidden first:pt-[1px]\">\n<div class=\"markdown prose dark:prose-invert w-full break-words light markdown-new-styling\">\n<p data-start=\"0\" data-end=\"52\">Active Ingredients: 5 Active Ingredients Complex<\/p>\n<p data-start=\"54\" data-end=\"187\">Structure and Composition:<br data-start=\"84\" data-end=\"87\" \/>Bicowhite\u00ae Complex contains five key active ingredients encapsulated using Bicosome\u00ae Technology:<\/p>\n<ul data-start=\"189\" data-end=\"538\">\n<li data-start=\"189\" data-end=\"282\">\n<p data-start=\"191\" data-end=\"282\">Potassium Azeloyl Diglycinate (1\u20135%) \u2013 an Azelaic acid derivative sourced from olives<\/p>\n<\/li>\n<li data-start=\"283\" data-end=\"353\">\n<p data-start=\"285\" data-end=\"353\">3-O-Ethyl Ascorbic Acid (1\u20135%) \u2013 a stable vitamin C derivative<\/p>\n<\/li>\n<li data-start=\"354\" data-end=\"393\">\n<p data-start=\"356\" data-end=\"393\">Niacinamide (1\u20135%) \u2013 vitamin B3<\/p>\n<\/li>\n<li data-start=\"394\" data-end=\"469\">\n<p data-start=\"396\" data-end=\"469\">Bisabolol (0.1\u20131.0%) \u2013 extracted from <em data-start=\"438\" data-end=\"467\">Vanillosmopsis erythropappa<\/em><\/p>\n<\/li>\n<li data-start=\"470\" data-end=\"538\">\n<p data-start=\"472\" data-end=\"538\">Phytic Acid (0.1\u20130.5%) \u2013 plant-derived phytic acid from corn<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"540\" data-end=\"758\">All five actives are encapsulated within Smart Disks, disc-shaped structures inside the Bicosome\u00ae system, composed of Lecithin, Lysolecithin, and Lactobacillus Ferment, which helps support skin balance.<\/p>\n<p data-start=\"794\" data-end=\"1216\">1. Penetration into Target Skin Layers (Multi-Target Delivery)<br data-start=\"860\" data-end=\"863\" \/>Upon application, Bicowhite\u00ae Complex penetrates the skin without disrupting its structure.<br data-start=\"953\" data-end=\"956\" \/>The outer vesicle fuses with the outermost layer, while the internal Smart Disks carrying the five actives are delivered directly to target layers. The actives are released precisely where needed, while the disks integrate with the skin&#8217;s lipid matrix.<\/p>\n<p data-start=\"1218\" data-end=\"1564\">2. Inhibition of Melanin Production \u2013 Potassium Azeloyl Diglycinate<br data-start=\"1289\" data-end=\"1292\" \/>This gentle Azelaic acid derivative inhibits tyrosinase, the key enzyme responsible for melanin synthesis.<br data-start=\"1402\" data-end=\"1405\" \/>By interacting with the enzyme\u2019s active site, it reduces the conversion of Tyrosine \u2192 DOPA \u2192 Dopaquinone, thereby lowering melanin formation at the source.<\/p>\n<p data-start=\"1566\" data-end=\"1874\">3. Prevention of Melanin Oxidation &amp; Darkening \u2013 3-O-Ethyl Ascorbic Acid<br data-start=\"1642\" data-end=\"1645\" \/>This highly stable vitamin C derivative prevents melanin oxidation\u2014an important process that makes pigmentation appear darker.<br data-start=\"1771\" data-end=\"1774\" \/>It can also convert dark melanin to reduced (lighter) melanin, helping fade existing dark spots.<\/p>\n<p data-start=\"1876\" data-end=\"2176\">4. Inhibition of Melanin Transfer \u2013 Niacinamide<br data-start=\"1927\" data-end=\"1930\" \/>Niacinamide blocks the transfer of melanin from melanocytes to keratinocytes by inhibiting PAR-2, a receptor involved in melanin transport.<br data-start=\"2081\" data-end=\"2084\" \/>Even if some melanin is still produced, it can no longer reach the skin surface effectively.<\/p>\n<p data-start=\"2178\" data-end=\"2414\">5. Anti-Inflammatory Protection \u2013 Bisabolol<br data-start=\"2225\" data-end=\"2228\" \/>Bisabolol reduces inflammation from sunlight, pollution, and external irritants\u2014factors that often trigger excess pigmentation.<br data-start=\"2355\" data-end=\"2358\" \/>It also soothes and calms the skin, reducing irritation.<\/p>\n<p data-start=\"2416\" data-end=\"2702\">6. Promotion of Cell Turnover \u2013 Phytic Acid<br data-start=\"2463\" data-end=\"2466\" \/>Phytic Acid acts as a chelating agent, binding metal ions (such as Cu\u00b2\u207a) essential for tyrosinase activity, reducing melanin production.<br data-start=\"2602\" data-end=\"2605\" \/>It also promotes cell turnover, helping to remove pigmented, damaged skin cells more quickly.<\/p>\n<p data-start=\"2704\" data-end=\"2893\">7. Targeted Action on Hyperpigmented Areas<br data-start=\"2750\" data-end=\"2753\" \/>Bicowhite\u00ae Complex works more intensely on hyperpigmented spots than on normal skin, reducing the risk of over-whitening or uneven tone.<\/p>\n<p data-start=\"2895\" data-end=\"3089\">8. Preservation of Skin Microstructures<br data-start=\"2938\" data-end=\"2941\" \/>Unlike harsh whitening agents that may damage the skin, Bicowhite\u00ae Complex preserves the natural microstructure, keeping skin healthy and resilient.<\/p>\n<hr data-start=\"3091\" data-end=\"3094\" \/>\n<h3 data-start=\"3096\" data-end=\"3112\">Benefits<\/h3>\n<ul data-start=\"3114\" data-end=\"3635\" data-is-last-node=\"\" data-is-only-node=\"\">\n<li data-start=\"3114\" data-end=\"3171\">\n<p data-start=\"3116\" data-end=\"3171\">Effectively reduces dark spots, melasma, and freckles<\/p>\n<\/li>\n<li data-start=\"3172\" data-end=\"3205\">\n<p data-start=\"3174\" data-end=\"3205\">Brightens and evens skin tone<\/p>\n<\/li>\n<li data-start=\"3206\" data-end=\"3247\">\n<p data-start=\"3208\" data-end=\"3247\">Enhances radiance and skin luminosity<\/p>\n<\/li>\n<li data-start=\"3248\" data-end=\"3315\">\n<p data-start=\"3250\" data-end=\"3315\">Targets dark spots without over-lightening the surrounding skin<\/p>\n<\/li>\n<li data-start=\"3316\" data-end=\"3404\">\n<p data-start=\"3318\" data-end=\"3404\">Safe for year-round use, including periods of strong sunlight (non\u2013photosensitizing)<\/p>\n<\/li>\n<li data-start=\"3405\" data-end=\"3449\">\n<p data-start=\"3407\" data-end=\"3449\">Preserves and strengthens skin structure<\/p>\n<\/li>\n<li data-start=\"3450\" data-end=\"3505\">\n<p data-start=\"3452\" data-end=\"3505\">Provides anti-aging benefits and reduces fine lines<\/p>\n<\/li>\n<li data-start=\"3506\" data-end=\"3580\">\n<p data-start=\"3508\" data-end=\"3580\">Suitable for all skincare products\u2014especially serums, creams, and gels<\/p>\n<\/li>\n<li data-start=\"3581\" data-end=\"3612\">\n<p data-start=\"3583\" data-end=\"3612\">Recommended usage: 1\u20133%<\/p>\n<\/li>\n<li data-start=\"3613\" data-end=\"3635\" data-is-last-node=\"\">\n<p data-start=\"3615\" data-end=\"3635\" data-is-last-node=\"\">Suitable pH: 4\u20138<\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/article>\n<p data-start=\"31\" data-end=\"67\"><strong data-start=\"31\" data-end=\"67\">Research Study by BICOSOME, S.L.<\/strong><\/p>\n<p data-start=\"69\" data-end=\"187\">Clinical Study on Pigmentation Reduction and Skin Brightening<br data-start=\"132\" data-end=\"135\" \/>(In Vivo Clinical Study \u2013 Melanin Index Reduction)<\/p>\n<p data-start=\"189\" data-end=\"545\">Method:<br data-start=\"200\" data-end=\"203\" \/>A study was conducted on 20 female volunteers aged 35\u201365 over a period of 56 days.<br data-start=\"285\" data-end=\"288\" \/>Participants applied a gel containing 3% Bicowhite\u00ae Complex twice daily (morning and evening) on the face.<br data-start=\"398\" data-end=\"401\" \/>The study took place during the summer season with strong sunlight exposure.<br data-start=\"477\" data-end=\"480\" \/>Evaluations were performed using multiple instruments, including:<\/p>\n<ul data-start=\"547\" data-end=\"701\">\n<li data-start=\"547\" data-end=\"591\">\n<p data-start=\"549\" data-end=\"591\">Mexameter\u00ae MX 18 (for Melanin Index)<\/p>\n<\/li>\n<li data-start=\"592\" data-end=\"655\">\n<p data-start=\"594\" data-end=\"655\">Spectrophotometer CM-700d (for brightness and radiance)<\/p>\n<\/li>\n<li data-start=\"656\" data-end=\"701\">\n<p data-start=\"658\" data-end=\"701\">Clinical assessments by expert evaluators<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"703\" data-end=\"715\">Results:<\/p>\n<p data-start=\"717\" data-end=\"738\">1. Melanin Index:<\/p>\n<ul data-start=\"740\" data-end=\"856\">\n<li data-start=\"740\" data-end=\"821\">\n<p data-start=\"742\" data-end=\"821\">Day 0: Melanin Index = 88 (difference between dark spots and normal skin)<\/p>\n<\/li>\n<li data-start=\"822\" data-end=\"856\">\n<p data-start=\"824\" data-end=\"856\">Day 56: Melanin Index = 64<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"858\" data-end=\"894\">Reduction: 26% (p = 0.00006)<\/p>\n<p data-start=\"858\" data-end=\"894\"><img decoding=\"async\" class=\"alignnone size-medium wp-image-37351\" src=\"https:\/\/www.asianbioplex.com\/wp-content\/uploads\/2025\/07\/image-_14_-300x244.webp\" alt=\"Melanin Index \" width=\"300\" height=\"244\" srcset=\"https:\/\/www.asianbioplex.com\/wp-content\/uploads\/2025\/07\/image-_14_-300x244.webp 300w, https:\/\/www.asianbioplex.com\/wp-content\/uploads\/2025\/07\/image-_14_-600x489.webp 600w, https:\/\/www.asianbioplex.com\/wp-content\/uploads\/2025\/07\/image-_14_.webp 652w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/p>\n<p data-start=\"31\" data-end=\"70\">2. Lightness (L) \u2013 Skin Brightness:<\/p>\n<ul data-start=\"72\" data-end=\"170\">\n<li data-start=\"72\" data-end=\"123\">\n<p data-start=\"74\" data-end=\"123\">Hyperpigmented areas: increased by 2.5%<\/p>\n<\/li>\n<li data-start=\"124\" data-end=\"170\">\n<p data-start=\"126\" data-end=\"170\">Normal skin areas: increased by 0.6%<\/p>\n<\/li>\n<\/ul>\n<p><img decoding=\"async\" class=\"alignnone size-medium wp-image-37354\" src=\"https:\/\/www.asianbioplex.com\/wp-content\/uploads\/2025\/07\/image-_15_-300x217.webp\" alt=\"Lightness\" width=\"300\" height=\"217\" srcset=\"https:\/\/www.asianbioplex.com\/wp-content\/uploads\/2025\/07\/image-_15_-300x217.webp 300w, https:\/\/www.asianbioplex.com\/wp-content\/uploads\/2025\/07\/image-_15_-600x434.webp 600w, https:\/\/www.asianbioplex.com\/wp-content\/uploads\/2025\/07\/image-_15_.webp 728w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/p>\n<p data-start=\"31\" data-end=\"72\">3. Number of Spots \u2013 Dark Spot Count:<\/p>\n<ul data-start=\"74\" data-end=\"168\">\n<li data-start=\"74\" data-end=\"121\">\n<p data-start=\"76\" data-end=\"121\">Day 28: decreased by 5% (p = 0.025)<\/p>\n<\/li>\n<li data-start=\"122\" data-end=\"168\">\n<p data-start=\"124\" data-end=\"168\">Day 56: decreased by 12% (p = 0.002)<\/p>\n<\/li>\n<\/ul>\n<p><img decoding=\"async\" class=\"alignnone size-medium wp-image-37358\" src=\"https:\/\/www.asianbioplex.com\/wp-content\/uploads\/2025\/07\/image-_16_-300x242.webp\" alt=\"Number of Spots\" width=\"300\" height=\"242\" srcset=\"https:\/\/www.asianbioplex.com\/wp-content\/uploads\/2025\/07\/image-_16_-300x242.webp 300w, https:\/\/www.asianbioplex.com\/wp-content\/uploads\/2025\/07\/image-_16_-600x485.webp 600w, https:\/\/www.asianbioplex.com\/wp-content\/uploads\/2025\/07\/image-_16_.webp 709w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/p>\n<p data-start=\"56\" data-end=\"606\">Summary of the Study:<br data-start=\"81\" data-end=\"84\" \/>Bicowhite\u00ae Complex demonstrated outstanding efficacy in brightening and evening out skin tone. It reduced the Melanin Index by 26%, decreased the darkness of hyperpigmented spots by 34%, improved overall skin uniformity by 35%, and reduced the number of dark spots by 12% within 56 days. Notably, the study was conducted during the summer under strong sunlight, yet the results remained excellent, confirming that Bicowhite\u00ae Complex can be used safely all year round without causing photosensitivity.<\/p>\n<p data-start=\"608\" data-end=\"991\">Additionally, the study found reductions in fine lines and wrinkles, highlighting its multi-benefit performance. Self-assessments from volunteers aligned with both clinical evaluations and instrumental measurements, confirming clear, visible, and highly satisfactory results. This makes Bicowhite\u00ae Complex ideal for developing high-performance and safe skin-brightening products.<\/p>\n<p>&nbsp;<\/p>\n<p data-start=\"83\" data-end=\"104\"><strong data-start=\"83\" data-end=\"104\">Research Study<\/strong><\/p>\n<p data-start=\"59\" data-end=\"652\">A study conducted by the Department of Dermatology, University of Barcelona investigated the use of a <em data-start=\"165\" data-end=\"192\">multi-ingredient approach<\/em> for reducing dark spots and melasma, focusing on inhibiting multiple stages of the melanogenesis pathway. The research demonstrated that combining ingredients that act on different mechanisms of melanin formation\u2014such as tyrosinase inhibition, prevention of melanin transfer, and protection against oxidation\u2014provides superior results compared to using a single active ingredient at a high concentration, with significantly lower irritation and better safety.<\/p>\n<p data-start=\"654\" data-end=\"1170\">The study also found that liposomal and vesicular delivery systems enhance the penetration of active ingredients into targeted skin layers more effectively than non-encapsulated actives. Clinical evaluations showed that subjects using formulations containing multiple actives delivered through advanced delivery systems experienced a significant reduction in dark spots and melasma, along with noticeable improvements in skin tone uniformity and overall brightness, without irritation or serious adverse effects.<\/p>\n<h6>Reference<br \/>\nKolbe, L., et al. &#8220;How to test efficacy of cosmetic skin-lightening products.&#8221; Journal of Cosmetic Dermatology, 2013, 12(3): 174-184<\/h6>\n<h3><b>\u0e04\u0e38\u0e13\u0e20\u0e32\u0e1e \u0e04\u0e27\u0e32\u0e21\u0e1b\u0e25\u0e2d\u0e14\u0e20\u0e31\u0e22 \u0e41\u0e25\u0e30\u0e01\u0e32\u0e23\u0e23\u0e31\u0e1a\u0e1b\u0e23\u0e30\u0e01\u0e31\u0e19<\/b><\/h3>\n<hr \/>\n<h3><b>Product Safety and Warranty Information<\/b><\/h3>\n<ul>\n<li>The product is manufactured through a certified process by leading organizations and has certification for industry standards that can be referenced.<\/li>\n<li>\n<div>The product is safe and can be used to support the registration of a cosmetic product.<\/div>\n<\/li>\n<li>The product is a raw material for industrial use, not a finished product. Users must have the knowledge and appropriate tools for using the raw material.<\/li>\n<li>The product is warranted according to the specifications, please refer to the <a href=\"https:\/\/www.asianbioplex.com\/en\/terms-conditions\">terms and conditions<\/a> for details.\n<ul>\n<li style=\"list-style-type: none\"><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<h3>(Price includes 7% VAT)<\/h3>\n<ul class=\"attr-list\">\n<li><span class=\"attr-name\" title=\"Part:\">From : Liquid<\/span><\/li>\n<li><span class=\"attr-name\" title=\"Place of Origin:\">Raw Material Origin : Spain<\/span><\/li>\n<li><span class=\"attr-name\" title=\"Grade:\">Grade :<\/span> Cosmetics<\/li>\n<li><span class=\"attr-name\" title=\"Botanical name:\">INCI Name : Water, Lecithin, Lysolecithin, Lactobacillus,Ferment, Niacinamide, 3-O-Ethyl Ascorbic Acid,<br \/>\nPotassium Azeloyl Diglycinate, Bisabolol,Phytic Acid, Tocopherol, Beta-Sitosterol, Squalene<\/span><\/li>\n<li>Shelf Life : 24 months from the date of manufacture (UNOPENED)<\/li>\n<\/ul>\n<p><img decoding=\"async\" class=\"alignnone wp-image-35072\" src=\"https:\/\/www.asianbioplex.com\/wp-content\/uploads\/2025\/07\/Bicosome-logo-web-ok-retina-300x153.webp\" alt=\"Bicosome-logo\" width=\"107\" height=\"55\" srcset=\"https:\/\/www.asianbioplex.com\/wp-content\/uploads\/2025\/07\/Bicosome-logo-web-ok-retina-300x153.webp 300w, https:\/\/www.asianbioplex.com\/wp-content\/uploads\/2025\/07\/Bicosome-logo-web-ok-retina-600x306.webp 600w, https:\/\/www.asianbioplex.com\/wp-content\/uploads\/2025\/07\/Bicosome-logo-web-ok-retina.webp 677w\" sizes=\"(max-width: 107px) 100vw, 107px\" \/>\u00a0 \u00a0 \u00a0<img decoding=\"async\" class=\"alignnone wp-image-3612\" src=\"http:\/\/www.asianbioplex.com\/wp-content\/uploads\/2018\/08\/JP_GMP.jpg\" alt=\"\" width=\"67\" height=\"56\" \/><img decoding=\"async\" class=\"alignnone wp-image-3611\" src=\"http:\/\/www.asianbioplex.com\/wp-content\/uploads\/2018\/08\/JP-ISO.jpg\" alt=\"\" width=\"127\" height=\"51\" srcset=\"https:\/\/www.asianbioplex.com\/wp-content\/uploads\/2018\/08\/JP-ISO.jpg 362w, https:\/\/www.asianbioplex.com\/wp-content\/uploads\/2018\/08\/JP-ISO-300x120.jpg 300w, https:\/\/www.asianbioplex.com\/wp-content\/uploads\/2018\/08\/JP-ISO-360x145.jpg 360w\" sizes=\"(max-width: 127px) 100vw, 127px\" \/><\/p>\n","protected":false},"featured_media":35420,"template":"","meta":[],"product_brand":[],"product_cat":[144],"product_tag":[],"class_list":{"0":"post-35078","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-extracts-for-cosmetics","7":"pa_size-1-kg","8":"pa_size-10-ml","9":"pa_size-100-g","10":"pa_size-100-ml","11":"pa_size-30-g","12":"pa_size-50-ml","13":"pa_size-500-g","15":"first","16":"instock","17":"taxable","18":"shipping-taxable","19":"purchasable","20":"product-type-variable"},"yoast_head":"<!-- This site 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