{"id":35194,"date":"2025-07-15T10:51:21","date_gmt":"2025-07-15T03:51:21","guid":{"rendered":"https:\/\/www.asianbioplex.com\/shop\/uncategorized\/beta-arbutin"},"modified":"2025-12-09T14:57:20","modified_gmt":"2025-12-09T07:57:20","slug":"beta-arbutin","status":"publish","type":"product","link":"https:\/\/www.asianbioplex.com\/en\/shop\/extracts-for-cosmetics\/beta-arbutin","title":{"rendered":"Beta Arbutin"},"content":{"rendered":"<h3>Beta Arbutin<\/h3>\n<article class=\"text-token-text-primary w-full focus:outline-none [--shadow-height:45px] has-data-writing-block:pointer-events-none has-data-writing-block:-mt-(--shadow-height) has-data-writing-block:pt-(--shadow-height) [&amp;:has([data-writing-block])&gt;*]:pointer-events-auto [content-visibility:auto] supports-[content-visibility:auto]:[contain-intrinsic-size:auto_100lvh] scroll-mt-[calc(var(--header-height)+min(200px,max(70px,20svh)))]\" dir=\"auto\" data-turn-id=\"request-689407d1-67d8-832e-8cf8-335daae6ff63-11\" data-testid=\"conversation-turn-500\" data-scroll-anchor=\"true\" data-turn=\"assistant\">\n<div class=\"text-base my-auto mx-auto pb-10 [--thread-content-margin:--spacing(4)] thread-sm:[--thread-content-margin:--spacing(6)] thread-lg:[--thread-content-margin:--spacing(16)] px-(--thread-content-margin)\">\n<div class=\"[--thread-content-max-width:40rem] thread-lg:[--thread-content-max-width:48rem] mx-auto max-w-(--thread-content-max-width) flex-1 group\/turn-messages focus-visible:outline-hidden relative flex w-full min-w-0 flex-col agent-turn\">\n<div class=\"flex max-w-full flex-col grow\">\n<div class=\"min-h-8 text-message relative flex w-full flex-col items-end gap-2 text-start break-words whitespace-normal [.text-message+&amp;]:mt-1\" dir=\"auto\" data-message-author-role=\"assistant\" data-message-id=\"dcbd1ea6-1ef7-41c7-83e4-a99b90495977\" data-message-model-slug=\"gpt-5\">\n<div class=\"flex w-full flex-col gap-1 empty:hidden first:pt-[1px]\">\n<div class=\"markdown prose dark:prose-invert w-full break-words light markdown-new-styling\">\n<p data-start=\"0\" data-end=\"488\" data-is-last-node=\"\" data-is-only-node=\"\">\u03b2-Arbutin (Beta-Arbutin) is a high-purity brightening ingredient (99.5%) manufactured by Kangcare Bioindustry Co., Ltd., China. It is a white crystalline powder that dissolves well in water. Chemically, it is a glucoside of hydroquinone linked to a glucose molecule via a \u03b2-glycosidic bond, which makes it significantly more stable and safer than regular hydroquinone.<br data-start=\"419\" data-end=\"422\" data-is-only-node=\"\" \/>It has a melting point of 199\u2013201\u00b0C and a pH range of 5.0\u20137.0, which is close to the natural pH of the skin. \u03b2-Arbutin works by inhibiting tyrosinase, the key enzyme responsible for melanin production, helping reduce dark spots, melasma, and freckles while promoting a brighter and more even skin tone.<br data-start=\"736\" data-end=\"739\" \/>It is ideal for those seeking luminous, clearer-looking skin and a more uniform complexion through an effective and safe brightening active.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/article>\n<table dir=\"ltr\" border=\"1\" cellspacing=\"0\" cellpadding=\"0\">\n<colgroup>\n<col width=\"219\" \/>\n<col width=\"492\" \/> <\/colgroup>\n<tbody>\n<tr>\n<th>Subject<\/th>\n<th>Description<\/th>\n<\/tr>\n<tr>\n<td>Appearance<\/td>\n<td>White Crystalline Fine Powder<\/td>\n<\/tr>\n<tr>\n<td>pH<\/td>\n<td>5.0 &#8211; 7.0<\/td>\n<\/tr>\n<tr>\n<td><span data-sheets-root=\"1\">Active ingredients<\/span><\/td>\n<td>Beta-arbutin 99.5%<\/td>\n<\/tr>\n<tr>\n<td>Applications<\/td>\n<td>Cosmetic products<\/td>\n<\/tr>\n<tr>\n<td>Suggested Concentration<\/td>\n<td>N\/A<\/td>\n<\/tr>\n<tr>\n<td><span data-sheets-root=\"1\">Function<\/span><\/td>\n<td>Protect Cream<\/td>\n<\/tr>\n<tr>\n<td>INCI Name<\/td>\n<td><em>\u03b1-Arbutin<\/em><\/td>\n<\/tr>\n<tr>\n<td>Storage conditions<\/td>\n<td><span data-sheets-root=\"1\">Store in a well-closed container away from moisture and direct sunlight.<\/span><\/td>\n<\/tr>\n<tr>\n<td>Shelf-Life<\/td>\n<td>24 months\u00a0 if sealed and stored properly.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p data-start=\"39\" data-end=\"777\">\u03b2-Arbutin stands out with its chemical structure as a glucoside of hydroquinone, where a glucose molecule is linked to hydroquinone through a \u03b2-glycosidic bond. This structure makes it more stable than \u03b1-arbutin and safer than regular hydroquinone, which is known to have cytotoxic effects on skin cells.<br data-start=\"351\" data-end=\"354\" \/>\u03b2-Arbutin has a high purity of 99.5% and a specific rotation of \u201364\u00b0 to \u201368\u00b0, which is characteristic of the true \u03b2-form structure. The product is highly stable, with moisture loss not exceeding 0.5%, and has a distinct melting point of 199\u2013201\u00b0C, confirming its purity and quality. Importantly, it contains very low levels of free hydroquinone, not more than 10 ppm, ensuring safety for cosmetic use.<\/p>\n<p data-start=\"779\" data-end=\"1111\">\u03b2-Arbutin dissolves well in water, making it easy to incorporate into various skincare formulations\u2014especially serums, creams, and lotions. It has a pH range of 5.0\u20137.0, which is skin-friendly and non-irritating. When properly sealed and stored in a dry place away from direct sunlight, it maintains a shelf life of 2 years.<\/p>\n<p>&nbsp;<\/p>\n<h3 data-start=\"213\" data-end=\"253\"><strong data-start=\"213\" data-end=\"253\">Mechanism of Action and Key Benefits<\/strong><\/h3>\n<p data-start=\"39\" data-end=\"86\"><strong data-start=\"39\" data-end=\"61\">Active Ingredient:<\/strong> \u03b2-Arbutin (Beta-Arbutin)<\/p>\n<p data-start=\"88\" data-end=\"533\">Chemical Structure: \u03b2-Arbutin has the molecular formula C\u2081\u2082H\u2081\u2086O\u2087 and a molecular weight of 272.25. It is a glucoside of hydroquinone, consisting of one glucose molecule linked to hydroquinone through a \u03b2-glycosidic bond at the C-1 position of the glucose. This \u03b2-form structure is more stable than the \u03b1-form and has a specific rotation of \u201364\u00b0 to \u201368\u00b0, which is a characteristic parameter confirming the purity of \u03b2-Arbutin.<\/p>\n<p data-start=\"936\" data-end=\"1183\"><img decoding=\"async\" class=\"size-medium wp-image-35116 aligncenter\" src=\"https:\/\/www.asianbioplex.com\/wp-content\/uploads\/2025\/07\/collagen-vitamin-skin-cell_1-300x167.webp\" alt=\"collagen-vitamin-skin-cell_1\" width=\"300\" height=\"167\" srcset=\"https:\/\/www.asianbioplex.com\/wp-content\/uploads\/2025\/07\/collagen-vitamin-skin-cell_1-300x167.webp 300w, https:\/\/www.asianbioplex.com\/wp-content\/uploads\/2025\/07\/collagen-vitamin-skin-cell_1-1024x569.webp 1024w, https:\/\/www.asianbioplex.com\/wp-content\/uploads\/2025\/07\/collagen-vitamin-skin-cell_1-768x427.webp 768w, https:\/\/www.asianbioplex.com\/wp-content\/uploads\/2025\/07\/collagen-vitamin-skin-cell_1-1536x853.webp 1536w, https:\/\/www.asianbioplex.com\/wp-content\/uploads\/2025\/07\/collagen-vitamin-skin-cell_1-2048x1138.webp 2048w, https:\/\/www.asianbioplex.com\/wp-content\/uploads\/2025\/07\/collagen-vitamin-skin-cell_1-600x333.webp 600w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/p>\n<ul>\n<li data-start=\"96\" data-end=\"183\">\n<p data-start=\"86\" data-end=\"110\"><strong data-start=\"86\" data-end=\"110\">Mechanism of Action:<\/strong><\/p>\n<p data-start=\"112\" data-end=\"533\"><strong data-start=\"112\" data-end=\"137\">Tyrosinase Inhibition<\/strong><br data-start=\"137\" data-end=\"140\" \/>\u03b2-Arbutin primarily works by inhibiting <strong data-start=\"180\" data-end=\"194\">tyrosinase<\/strong>, the key enzyme involved in melanin production (melanogenesis). Tyrosinase converts L-tyrosine to L-DOPA and subsequently to dopaquinone, which are early steps in melanin synthesis. \u03b2-Arbutin binds to the enzyme\u2019s <strong data-start=\"409\" data-end=\"424\">active site<\/strong>, which contains copper ions (Cu\u00b2\u207a), thereby reducing the enzyme\u2019s activity and decreasing melanin formation.<\/p>\n<p data-start=\"535\" data-end=\"853\"><strong data-start=\"535\" data-end=\"561\">Competitive Inhibition<\/strong><br data-start=\"561\" data-end=\"564\" \/>Because the hydroquinone portion of \u03b2-Arbutin structurally resembles L-tyrosine, the natural substrate of tyrosinase, \u03b2-Arbutin can compete with L-tyrosine for binding to the enzyme. When \u03b2-Arbutin occupies the active site instead of L-tyrosine, the melanin-formation pathway is inhibited.<\/p>\n<p data-start=\"855\" data-end=\"1317\"><strong data-start=\"855\" data-end=\"902\">Controlled and Safe Release of Hydroquinone<\/strong><br data-start=\"902\" data-end=\"905\" \/>When \u03b2-Arbutin comes into contact with the skin, the enzyme <strong data-start=\"965\" data-end=\"982\">\u03b2-glucosidase<\/strong> gradually cleaves the \u03b2-glycosidic bond, slowly releasing hydroquinone in small, controlled amounts. The released hydroquinone is effective in inhibiting melanin formation, but because the release is slow and protected by the glucose molecule, \u03b2-Arbutin is far safer than regular hydroquinone, which can irritate or damage skin cells.<\/p>\n<p data-start=\"1319\" data-end=\"1655\"><strong data-start=\"1319\" data-end=\"1362\">Reduction of Existing Hyperpigmentation<\/strong><br data-start=\"1362\" data-end=\"1365\" \/>In addition to preventing new melanin formation, \u03b2-Arbutin also helps reduce existing pigmentation by inhibiting the conversion of DOPA into melanin polymers, resulting in lighter pigment formation. By promoting <strong data-start=\"1577\" data-end=\"1594\">cell turnover<\/strong>, it also accelerates the removal of melanin-rich skin cells.<\/p>\n<p data-start=\"1657\" data-end=\"2063\"><strong data-start=\"1657\" data-end=\"1679\">Safety &amp; Stability<\/strong><br data-start=\"1679\" data-end=\"1682\" \/>\u03b2-Arbutin is highly stable, as the \u03b2-glycosidic bond does not break down easily, preventing the excessive release of free hydroquinone at once. The product contains very low levels of free hydroquinone (&lt;10 ppm), confirming its safety. \u03b2-Arbutin is also stable under light, heat, and cosmetic pH ranges (pH 5.0\u20137.0), making it suitable for formulations that require high stability.<\/p>\n<p data-start=\"2065\" data-end=\"2250\"><strong data-start=\"2065\" data-end=\"2089\">Non-Photosensitizing<\/strong><br data-start=\"2089\" data-end=\"2092\" \/>\u03b2-Arbutin does not cause photosensitivity and can be used year-round, even under strong sunlight, without increasing the risk of hyperpigmentation or sunburn.<\/p>\n<hr data-start=\"2252\" data-end=\"2255\" \/>\n<p data-start=\"2257\" data-end=\"2270\"><strong data-start=\"2257\" data-end=\"2270\">Benefits:<\/strong><\/p>\n<ul data-start=\"2272\" data-end=\"2730\">\n<li data-start=\"2272\" data-end=\"2313\">\n<p data-start=\"2274\" data-end=\"2313\">Effectively inhibits melanin production<\/p>\n<\/li>\n<li data-start=\"2314\" data-end=\"2374\">\n<p data-start=\"2316\" data-end=\"2374\">Reduces dark spots, melasma, freckles, and post-acne marks<\/p>\n<\/li>\n<li data-start=\"2375\" data-end=\"2406\">\n<p data-start=\"2377\" data-end=\"2406\">Brightens and evens skin tone<\/p>\n<\/li>\n<li data-start=\"2407\" data-end=\"2440\">\n<p data-start=\"2409\" data-end=\"2440\">Safer than regular hydroquinone<\/p>\n<\/li>\n<li data-start=\"2441\" data-end=\"2493\">\n<p data-start=\"2443\" data-end=\"2493\">Highly stable; does not discolor or degrade easily<\/p>\n<\/li>\n<li data-start=\"2494\" data-end=\"2545\">\n<p data-start=\"2496\" data-end=\"2545\">Non-photosensitizing; suitable for year-round use<\/p>\n<\/li>\n<li data-start=\"2546\" data-end=\"2590\">\n<p data-start=\"2548\" data-end=\"2590\">Highly water-soluble and easy to formulate<\/p>\n<\/li>\n<li data-start=\"2591\" data-end=\"2674\">\n<p data-start=\"2593\" data-end=\"2674\">Suitable for all skincare products, especially serums, creams, lotions, and masks<\/p>\n<\/li>\n<li data-start=\"2675\" data-end=\"2730\">\n<p data-start=\"2677\" data-end=\"2730\">Skin-friendly pH range that does not cause irritation<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h3 data-start=\"130\" data-end=\"155\"><strong data-start=\"134\" data-end=\"155\">Research Study<\/strong><\/h3>\n<p data-start=\"59\" data-end=\"494\">A study conducted by the Department of Dermatology, Kyoto University compared the efficacy and safety of \u03b2-Arbutin with other skin-brightening agents such as \u03b1-arbutin and hydroquinone. The results showed that \u03b2-Arbutin is significantly more stable than \u03b1-arbutin, particularly under conditions involving light and heat, and is considerably safer than hydroquinone, as it does not cause skin irritation or cytotoxicity.<\/p>\n<p data-start=\"496\" data-end=\"997\">In vitro tests demonstrated that \u03b2-Arbutin effectively inhibits tyrosinase, with a low IC\u2085\u2080 value, indicating strong inhibitory activity. Studies on melanocyte cells further confirmed that \u03b2-Arbutin can significantly reduce melanin production without adversely affecting cell growth. Additionally, the presence of a \u03b2-glycosidic bond in \u03b2-Arbutin allows for the slow and controlled release of hydroquinone, enhancing its skin-brightening efficacy while minimizing the risk of side effects.<\/p>\n<h6>Reference<br \/>\nSugimoto, K., et al. &#8220;Inhibitory effects of \u03b1- and \u03b2-arbutin on melanin synthesis in cultured human melanoma cells and a three-dimensional human skin model.&#8221; Biological and Pharmaceutical Bulletin, 2004, 27(4): 510-514<\/h6>\n<h3><b>Product Safety and Warranty Information<\/b><\/h3>\n<ul>\n<li>The product is manufactured through a certified process by leading organizations and has certification for industry standards that can be referenced.<\/li>\n<li>\n<div>The product is safe and can be used to support the registration of a cosmetic product.<\/div>\n<\/li>\n<li>The product is a raw material for industrial use, not a finished product. Users must have the knowledge and appropriate tools for using the raw material.<\/li>\n<li>The product is warranted according to the specifications, please refer to the <a href=\"https:\/\/www.asianbioplex.com\/en\/terms-conditions\">terms and conditions<\/a> for details.\n<ul>\n<li style=\"list-style-type: none\"><\/li>\n<\/ul>\n<\/li>\n<li style=\"list-style-type: none\">\n<ul>\n<li style=\"list-style-type: none\"><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<h3>(Price includes 7% VAT)<\/h3>\n<ul class=\"attr-list\">\n<li><span class=\"attr-name\" title=\"Part:\">From : Powder<\/span><\/li>\n<li><span class=\"attr-name\" title=\"Place of Origin:\">Raw Material Origin : China<\/span><\/li>\n<li><span class=\"attr-name\" title=\"Grade:\">Grade :<\/span> Cosmetics<\/li>\n<li><span class=\"attr-name\" title=\"Botanical name:\">INCI Name\u00a0: \u03b2-Arbutin<\/span><\/li>\n<li>Shelf Life : 24 months if sealed and stored properly.<\/li>\n<\/ul>\n<p><img decoding=\"async\" class=\"alignnone wp-image-3612\" src=\"http:\/\/www.asianbioplex.com\/wp-content\/uploads\/2018\/08\/JP_GMP.jpg\" alt=\"\" width=\"67\" height=\"56\" \/><img decoding=\"async\" class=\"alignnone wp-image-3611\" src=\"http:\/\/www.asianbioplex.com\/wp-content\/uploads\/2018\/08\/JP-ISO.jpg\" alt=\"\" width=\"127\" height=\"51\" srcset=\"https:\/\/www.asianbioplex.com\/wp-content\/uploads\/2018\/08\/JP-ISO.jpg 362w, https:\/\/www.asianbioplex.com\/wp-content\/uploads\/2018\/08\/JP-ISO-300x120.jpg 300w, https:\/\/www.asianbioplex.com\/wp-content\/uploads\/2018\/08\/JP-ISO-360x145.jpg 360w\" sizes=\"(max-width: 127px) 100vw, 127px\" 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