Description
Bicowhite® Complex
Bicowhite® Complex is a multi-target delivery system for brightening and evening the skin tone, developed using Bicosome® Technology by BICOSOME, S.L., Spain. It is made from 95.3% natural ingredients and contains five key actives encapsulated within Smart Disk structures: Niacinamide, 3-O-Ethyl Ascorbic Acid, Potassium Azeloyl Diglycinate, Bisabolol, and Phytic Acid. These actives work synergistically to inhibit the formation of dark spots from the very beginning of the pigmentation process.
The product is designed to address the main challenges of typical brightening formulations by offering both high efficacy and excellent skin tolerance. It targets only areas with hyperpigmentation without damaging skin structure, and it can be used year-round without causing photosensitivity.
It is ideal for individuals seeking to reduce dark spots, melasma, and freckles while achieving brighter, more even-toned, and healthier-looking skin.
| Subject | Description |
|---|---|
| Appearance | Liquid |
| pH | 4.0 – 6.0 |
| Composition | -AQUA Up to 100 -LECITHIN 5-25% -LYSOLECITHIN 2-20% -LACTOBACILLUS FERMENT 1-5% -NIACINAMIDE 1-5% -3-0-ETHYL ASCORBIC ACID 1-5% -POTASSIUM AZELOYL DIGLYCINATE 1-5% -BISABOLOL 0.1-1.0% -PHYTIC ACID 0.1 – 0.5% |
| Applications | Cosmetic products |
| Suggested Concentration | 1 – 3% |
| Function | Whitening |
| INCI Name | Water, Lecithin, Lysolecithin, Lactobacillus Ferment, Niacinamide, 3-O-Ethyl Ascorbic Acid, Potassium Azeloyl Diglycinate, Bisabolol, Phytic Acid, Tocopherol, Beta-Sitosterol, Squalene |
| Storage conditions | Store the product tightly closed in a dry place at no more than 8ºC and protected from light. It is recommended to stir the full content of the container before use or fractioning to assure adequate homogeneity. Use soon after opening the package. The stability studies data indicate the product can be transported and manipulated at temperature of 25ºC without instability risks. |
| Shelf-Life | 24 months from manufacturing date |
Bicowhite® Complex stands out for its innovative delivery system that transports five active ingredients simultaneously to targeted skin layers using Bicosome® Technology. This system features a dual structure composed of an outer lipidic vesicle and internal Smart Disks that encapsulate all five key actives. Each ingredient targets a specific stage of the melanin-production process:
-
Potassium Azeloyl Diglycinate – inhibits melanin synthesis
-
3-O-Ethyl Ascorbic Acid – prevents oxidation and darkening of existing pigment
-
Niacinamide – prevents the transfer of melanin to skin cells
-
Bisabolol – reduces inflammation that can trigger excess pigmentation
-
Phytic Acid – promotes skin cell renewal
In vitro studies show that Bicowhite® Complex reduces pigmentation by up to 32% within 4 days, while maintaining better skin structure compared to Kojic Acid.
Ex vivo testing on UV-exposed skin demonstrated a 154% reduction in pigmentation after 10 days, confirming its effectiveness even under strong sunlight conditions.
The product has passed safety evaluations, including non-irritant and non-phototoxic tests, and is certified Vegan, Non-GMO, and China NMPA Compliant.
Recommended usage level: 1–3% in all types of skincare formulations.
Mechanism of action
Active Ingredients: 5 Active Ingredients Complex
Structure and Composition:
Bicowhite® Complex contains five key active ingredients encapsulated using Bicosome® Technology:
-
Potassium Azeloyl Diglycinate (1–5%) – an Azelaic acid derivative sourced from olives
-
3-O-Ethyl Ascorbic Acid (1–5%) – a stable vitamin C derivative
-
Niacinamide (1–5%) – vitamin B3
-
Bisabolol (0.1–1.0%) – extracted from Vanillosmopsis erythropappa
-
Phytic Acid (0.1–0.5%) – plant-derived phytic acid from corn
All five actives are encapsulated within Smart Disks, disc-shaped structures inside the Bicosome® system, composed of Lecithin, Lysolecithin, and Lactobacillus Ferment, which helps support skin balance.
1. Penetration into Target Skin Layers (Multi-Target Delivery)
Upon application, Bicowhite® Complex penetrates the skin without disrupting its structure.
The outer vesicle fuses with the outermost layer, while the internal Smart Disks carrying the five actives are delivered directly to target layers. The actives are released precisely where needed, while the disks integrate with the skin’s lipid matrix.
2. Inhibition of Melanin Production – Potassium Azeloyl Diglycinate
This gentle Azelaic acid derivative inhibits tyrosinase, the key enzyme responsible for melanin synthesis.
By interacting with the enzyme’s active site, it reduces the conversion of Tyrosine → DOPA → Dopaquinone, thereby lowering melanin formation at the source.
3. Prevention of Melanin Oxidation & Darkening – 3-O-Ethyl Ascorbic Acid
This highly stable vitamin C derivative prevents melanin oxidation—an important process that makes pigmentation appear darker.
It can also convert dark melanin to reduced (lighter) melanin, helping fade existing dark spots.
4. Inhibition of Melanin Transfer – Niacinamide
Niacinamide blocks the transfer of melanin from melanocytes to keratinocytes by inhibiting PAR-2, a receptor involved in melanin transport.
Even if some melanin is still produced, it can no longer reach the skin surface effectively.
5. Anti-Inflammatory Protection – Bisabolol
Bisabolol reduces inflammation from sunlight, pollution, and external irritants—factors that often trigger excess pigmentation.
It also soothes and calms the skin, reducing irritation.
6. Promotion of Cell Turnover – Phytic Acid
Phytic Acid acts as a chelating agent, binding metal ions (such as Cu²⁺) essential for tyrosinase activity, reducing melanin production.
It also promotes cell turnover, helping to remove pigmented, damaged skin cells more quickly.
7. Targeted Action on Hyperpigmented Areas
Bicowhite® Complex works more intensely on hyperpigmented spots than on normal skin, reducing the risk of over-whitening or uneven tone.
8. Preservation of Skin Microstructures
Unlike harsh whitening agents that may damage the skin, Bicowhite® Complex preserves the natural microstructure, keeping skin healthy and resilient.
Benefits
-
Effectively reduces dark spots, melasma, and freckles
-
Brightens and evens skin tone
-
Enhances radiance and skin luminosity
-
Targets dark spots without over-lightening the surrounding skin
-
Safe for year-round use, including periods of strong sunlight (non–photosensitizing)
-
Preserves and strengthens skin structure
-
Provides anti-aging benefits and reduces fine lines
-
Suitable for all skincare products—especially serums, creams, and gels
-
Recommended usage: 1–3%
-
Suitable pH: 4–8
Research Study by BICOSOME, S.L.
Clinical Study on Pigmentation Reduction and Skin Brightening
(In Vivo Clinical Study – Melanin Index Reduction)
Method:
A study was conducted on 20 female volunteers aged 35–65 over a period of 56 days.
Participants applied a gel containing 3% Bicowhite® Complex twice daily (morning and evening) on the face.
The study took place during the summer season with strong sunlight exposure.
Evaluations were performed using multiple instruments, including:
-
Mexameter® MX 18 (for Melanin Index)
-
Spectrophotometer CM-700d (for brightness and radiance)
-
Clinical assessments by expert evaluators
Results:
1. Melanin Index:
-
Day 0: Melanin Index = 88 (difference between dark spots and normal skin)
-
Day 56: Melanin Index = 64
Reduction: 26% (p = 0.00006)
2. Lightness (L) – Skin Brightness:
-
Hyperpigmented areas: increased by 2.5%
-
Normal skin areas: increased by 0.6%
3. Number of Spots – Dark Spot Count:
-
Day 28: decreased by 5% (p = 0.025)
-
Day 56: decreased by 12% (p = 0.002)
Summary of the Study:
Bicowhite® Complex demonstrated outstanding efficacy in brightening and evening out skin tone. It reduced the Melanin Index by 26%, decreased the darkness of hyperpigmented spots by 34%, improved overall skin uniformity by 35%, and reduced the number of dark spots by 12% within 56 days. Notably, the study was conducted during the summer under strong sunlight, yet the results remained excellent, confirming that Bicowhite® Complex can be used safely all year round without causing photosensitivity.
Additionally, the study found reductions in fine lines and wrinkles, highlighting its multi-benefit performance. Self-assessments from volunteers aligned with both clinical evaluations and instrumental measurements, confirming clear, visible, and highly satisfactory results. This makes Bicowhite® Complex ideal for developing high-performance and safe skin-brightening products.
Research Study
A study conducted by the Department of Dermatology, University of Barcelona investigated the use of a multi-ingredient approach for reducing dark spots and melasma, focusing on inhibiting multiple stages of the melanogenesis pathway. The research demonstrated that combining ingredients that act on different mechanisms of melanin formation—such as tyrosinase inhibition, prevention of melanin transfer, and protection against oxidation—provides superior results compared to using a single active ingredient at a high concentration, with significantly lower irritation and better safety.
The study also found that liposomal and vesicular delivery systems enhance the penetration of active ingredients into targeted skin layers more effectively than non-encapsulated actives. Clinical evaluations showed that subjects using formulations containing multiple actives delivered through advanced delivery systems experienced a significant reduction in dark spots and melasma, along with noticeable improvements in skin tone uniformity and overall brightness, without irritation or serious adverse effects.
Reference
Kolbe, L., et al. “How to test efficacy of cosmetic skin-lightening products.” Journal of Cosmetic Dermatology, 2013, 12(3): 174-184
คุณภาพ ความปลอดภัย และการรับประกัน
Product Safety and Warranty Information
- The product is manufactured through a certified process by leading organizations and has certification for industry standards that can be referenced.
-
The product is safe and can be used to support the registration of a cosmetic product.
- The product is a raw material for industrial use, not a finished product. Users must have the knowledge and appropriate tools for using the raw material.
- The product is warranted according to the specifications, please refer to the terms and conditions for details.
