Bionanoceramide EX

Description

Bionanoceramide EX – Advanced Bio-Nano Ceramide Innovation

BIONANOCERAMIDE EX is an innovative Glycosphingolipid (Glycosyl Ceramide) developed through a fermentation process derived from bacterial cell membranes. It is engineered into nano-sized particles and a liposomal structure, enabling exceptional penetration into the outermost layer of the skin. With this advanced technology, BIONANOCERAMIDE EX effectively enhances moisture retention and rapidly restores the integrity of the skin barrier.

BIONANOCERAMIDE EX : is a highly concentrated Glycosphingolipid (Glycosyl Ceramide) at 5.0%, formulated using cutting-edge nano-sizing technology, achieving an average particle size of approximately 70 nanometers (70 nm) in a multi-layer liposome structure. This ultra-fine size not only provides high transparency to formulations but also significantly boosts the delivery and absorption efficiency of the active ingredient into the skin—offering deeper and longer-lasting benefits compared to conventional ceramides.

Mechanism of Action and Key Benefits of Bionanoceramide EX
Primary Active Ingredient: Glycosphingolipids (Glycosyl Ceramide)

Glycosphingolipids, also known as Glycosyl Ceramides, are essential bio-ceramides that play a critical role in skin function. They act as the “cement” that holds corneocytes together in the outermost layer of the skin, forming a strong protective barrier and maintaining proper moisture balance.

Mechanism of Action and Properties

BIONANOCERAMIDE EX provides superior performance compared to conventional ceramides, thanks to its nano-liposome innovation, which enhances the skin in three key dimensions:

Penetration and Delivery
Nano-Liposome Technology :
By reducing the particle size of Glycosphingolipids to 70 nm and forming a Multi-Layer Liposome structure, the active ingredient achieves excellent biocompatibility with the skin. This allows it to penetrate the stratum corneum—a major barrier to active delivery—with exceptional efficiency. As a result, the actives take effect more quickly and more precisely.

Barrier Function Improvement
Strengthening the Skin Barrier :
Once delivered to targeted areas, the ceramides help fill gaps within the lipid matrix and reinforce weakened barrier structures.

Reduced Moisture Loss :
A well-functioning barrier helps lower Transepidermal Water Loss (TEWL), enabling the skin to retain moisture for longer and become more resilient.

Long-Lasting Moisturization
Moisture Balance Restoration:
With superior absorption, BIONANOCERAMIDE EX supports rapid restoration of optimal moisture levels within the outermost skin layer.

When used together with Sodium Hyaluronate, it delivers a powerful synergistic effect, significantly enhancing and prolonging skin hydration.

Summary of Manufacturer’s Research Findings: Innovation and Enhanced Skin Penetration

A comparative study was conducted to evaluate the penetration efficiency of Glycosphingolipids (Glycosyl Ceramide) into the stratum corneum. The test compared the standard (non-nano) form of Glycosphingolipids with BIONANOCERAMIDE EX, the nano-engineered version featuring a liposomal structure. The results demonstrate significantly improved penetration with the nano-liposome formulation.

Test Method

Sample Preparation : Glycosphingolipids (Glycosyl Ceramide) were fluorescently labeled and prepared into two types of test solutions

• A non–nano-processed solution
• BIONANOCERAMIDE EX (nano-processed solution)

Application : Both samples were applied to the epidermal layer of a 3D skin model.

Measurement : The fluorescence intensity within the skin was measured and expressed as relative figures after 2 hours and 8 hours (with the penetration level of the non-nano Glycosphingolipids at 2 hours set as “1”).

Test Results

• At 8 hours: BIONANOCERAMIDE EX showed approximately 3 times higher penetration (relative figures) into the skin compared to standard Glycosphingolipids.

• Fluorescence microscopy images clearly demonstrated deeper and more pronounced penetration of BIONANOCERAMIDE EX into the epidermal layer.

Conclusion

The innovation behind reducing the particle size to approximately 70 nm, combined with the multi-layer liposome structure, is the key factor that enables BIONANOCERAMIDE EX to penetrate the epidermis with exceptional efficiency. This enhanced penetration directly contributes to its superior moisturizing performance and its ability to restore and reinforce the skin barrier.

Research Findings

A study conducted by Kyoto University found that glycosphingolipids, a key component of skin ceramides, play a vital role in maintaining the structural integrity of the skin’s protective barrier. Topical supplementation with glycosyl ceramide has been shown to significantly improve the skin’s moisture retention ability and reduce transepidermal water loss (TEWL), particularly in individuals with dry skin or impaired skin barrier function.

Reference
Sugawara, T., et al. (2009). Dietary glycosylceramide improves skin barrier function in hairless mice. Kyoto University, Journal of Agricultural and Food Chemistry.

Product Safety and Warranty Information

• The product is manufactured through a certified process by leading organizations and has certification for industry standards that can be referenced.
• The product is safe and can be used to support the registration of a cosmetic product.
• The product is a raw material for industrial use, not a finished product. Users must have the knowledge and appropriate tools for using the raw material.
• The product is warranted according to the specifications, please refer to the terms and conditions for details.